CBD Oil Tolerance


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If you've recently found your CBD oil ineffective or you've never had any luck with CBD oils, your dose may be to blame. However, there can also be other factors at play, including poor quality CBD oils or how you're taking CBD. Over time, as we introduce either plant-based or synthetic compounds into our bodies, we be What does it mean to tolerate something? For most, the word tolerance boils down to gradually learning to put up with something previously deemed irritating or overstimulating, or to adapt to a stimulus that is foreign to the body. If we nix the negative connotation often tied to tolerating a person or thing, CBD toler

Can You Build CBD Tolerance?

If you’ve recently found your CBD oil ineffective or you’ve never had any luck with CBD oils, your dose may be to blame. However, there can also be other factors at play, including poor quality CBD oils or how you’re taking CBD.

Over time, as we introduce either plant-based or synthetic compounds into our bodies, we begin to develop tolerance. Due to this phenomenon, you may need higher doses of the substance to get the same level of desired effect unlike THC.

We’ll break down everything you need to know about CBD tolerance, safety, and how to source quality CBD products in this article.

Can You Take Too Much CBD?

Yes, you can take too much CBD.

That being said, CBD has been proven safe, even in high quantities, and won’t lead to lethal overdose [1]. But this isn’t to say you won’t experience any discomfort if you take too much. Any compound that alters the way you feel has the potential for adverse side-effects — though some much more severe than others.

Here are some common side effects of CBD overdose:

Thankfully, the aftermath of taking too much CBD wears off as soon as it’s out of your system, within 2–3 hours. However, to avoid any chances of discomfort, you should start with lower doses and build up gradually over time until you reach your desired effects.

Keep in mind, CBD can create undesired outcomes when taken with other medications, which is why you must speak with your doctor before using CBD oil to treat a condition.

5 Reasons Why CBD is Not Working for You

It can be frustrating to try numerous CBD products, only to find nothing but wasted money and disappointment in your purchases. There can be several contributing factors as to why your CBD is not working and here we’ll go over the common problems while offering solutions for each.

1. You’re Using Low-Quality CBD Products

The CBD industry is relatively new and poorly regulated. Unfortunately, there are companies out there selling fake CBD oil that contains very little CBD or harvesting CBD from contaminated hemp sources.

Before you purchase a CBD product, check for third-party lab tests and read online consumer reviews.

Reputable brands send samples of their products to non-biased, third-party labs to ensure quality control measures are met. These labs test for CBD content and potential contamination from harmful solvents, heavy metals, pesticides, or mycotoxins (mold).

You want to verify that the CBD content on the test matches and fewer cannabinoid receptors what’s labeled on the bottle and that the extract is free from contamination that can render the CBD ineffective or potentially dangerous.

2. You Need To Find The Right Dose

If you’re just getting started with CBD and you’re not getting the desired effects, chances are you haven’t found the right dose. The tricky thing about dosing is that everyone responds to CBD differently. Your ideal dose will depend on various factors, including genetics, experience with medical cannabis, metabolism, and health conditions.

You can expect to experiment with your CBD doses, but start with smaller amounts and build up gradually over a few days until you find your Goldilocks zone. It may help to make note of your doses in a journal or your notes app on your phone to track how much CBD you’re taking.

3. You Need To Use CBD Consistently

While CBD has been proven effective for many health benefits, it’s not an overnight fix-all compound.

People will often buy CBD oil thinking it works like Tylenol for instant pain relief — but it just doesn’t work that way. Aside from finding the appropriate dose unique to you, it can take CBD days or several weeks of THC tolerance before you experience a noticeable difference in how you feel.

CBD isn’t particularly good at binding to receptors that activate an immediate response. Consistent use of CBD oil maintains the body’s endocannabinoid system function by making the receptors more sensitive to stimulation from internal cannabinoids.

In addition to giving prescription medications CBD some time to work, we recommend taking your CBD at the same time each day with your vitamins for overall health support or an hour before bed as part of your winding down routine if you’re looking to use CBD to improve sleep quality.

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4. You’re Using The Wrong Delivery Method

Cannabinoid receptors are located throughout the body, which allows CBD users to enjoy different delivery methods for consuming CBD from CBD oils, capsules, sprays, gummies, and skincare.

However, the effects you’re looking to experience with CBD can depend on the delivery method you choose. For example, topical CBD formulas like lotions and salves work well for relieving localized muscle aches from a strenuous gym session, but it won’t help support a normal digestive process or mood because it doesn’t enter the bloodstream.

Do you find vaping CBD products to work well initially, but it seems to taper off quickly? This is because CBD inhalation is the fastest delivery method as it bypasses the digestive system that can breakdown the active compounds before entering the bloodstream. However, the effects of smoking CBD also wear off faster.

If this is the issue, consider taking a break from smokable products and use edible forms of CBD instead such as capsules, oils, or gummies.

5. You’ve Built A Tolerance To CBD

It’s possible that you’ve built a tolerance to CBD when you feel like your CBD product isn’t working as well as it used to.

Long term CBD users are likely to experience tolerance and have to increase their doses to get the same level of effects. A high tolerance can make CBD use expensive. However, it’s possible to reduce your threshold if you take a CBD tolerance break.

A tolerance break means you stop taking the substance you’ve built a tolerance to in order to let it completely run its course from your system. There isn’t a scientific rule for how long you should take a break from CBD — but many people report 3-7 days seems to do the trick to reset their system.

Tolerance breaks, much like dosing CBD, is an individual affair that requires experimentation and observation. It may be helpful to record your doses before you go on a tolerance break so you can have a reference to look back on for future dosing with a more accurate assessment of your condition before, during, and after you temporarily abstain from CBD use.

Here’s what to record if you should decide to take a CBD tolerance break: how long you’ve been using CBD, your doses before the break, symptoms, how many days of tolerance break, symptoms during break, doses after the break, increasing doses gradually, note any changes in symptoms or side-effects.

How Fast Does CBD Tolerance Build?

It’s difficult to say how quickly CBD oil tolerance builds because it’s different for every individual and your CBD doses may fluctuate depending on the state of your health and your current lifestyle.

The endocannabinoid system is responsible for regulating homeostasis (balance) in the body, which means you may need more or less CBD at any given time. Dosing CBD oil that’s right for you comes with a lot of trial and practice — so there’s no one size fits all approach to dosing.

Tolerance depends on a variety of factors, including:

CBD Tolerance vs. CBD Dependence

Defining Substance Tolerance

The word tolerance is often associated with drug addiction and the negative consequences of a condition called dependence that can be dangerous. Let’s quickly run through the differences of substance tolerance and dependence.

Tolerance is what occurs when your body loses sensitivity to a compound to elicit the desired outcome. Just as you can build a tolerance to caffeine, your system can build a tolerance to CBD.

The effect of tolerance makes users consume more of the substance to achieve the same level of impact because their body has lost sensitivity to the active compound.

Defining Substance Dependence & Withdrawals

Dependence is what happens when a user goes through withdrawal symptoms, which can include both physical and emotional disruption.

Withdrawal symptoms can be as mild as headaches, moodiness, or fatigue due to caffeine withdrawals, or more life-threatening, such as a fast heart rate, muscle pain, depression, and vomiting from withdrawals.

These severe withdrawals create a dependence on the substance in order to avoid adverse symptoms. The body becomes dependent on the compound and now needs it to reach a level of homeostasis (balance).

When it comes to CBD, you can build a tolerance. However, severe withdrawal symptoms are highly unlikely to develop, even for long term users [2]. The most discomfort felt in a randomized CBD trial that investigated what happens when users take an abrupt break from regular use included headaches and diarrhea.

You’re not likely to experience a CBD dependence because it doesn’t produce withdrawal symptoms when you’re not using it.

What Is Reverse Tolerance?

Reverse tolerance is when you require less of a compound to reach the desired effects — opposite to building tolerance. You become more sensitive to the compound, which can be a positive or negative, depending on the compound.

Some anecdotal evidence suggests that CBD has this reverse tolerance effect with long-term use, but there’s still a lot of medical research needed to confirm this. It’s more likely that it takes a long time to develop a tolerance to CBD in general because of it’s unique interaction with the endocannabinoid system.

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Our body’s receptors rely on chemical messengers to send signals for actions within the body. Most compounds that build tolerance in the body bind with these receptors to elicit a specific action. With prolonged exposure to the chemical messenger, the receptors lose their sensitivity.

CBD isn’t efficient at binding to CB1 or CB2 receptors, like its famous psychoactive counterpart, THC is.

Continued use of THC has been shown to increase the body’s tolerance [3]. However, consuming CBD with THC has shown to improve THC interactions, which is one of the reasons that have lead researchers to believe that CBD tolerance either isn’t real or there is a reverse tolerance occurring.

CBD doesn’t directly unlock actions on the CB1 or CB2 receptors in the endocannabinoid system. Rather, CBD promotes receptor activity, which helps facilitate the binding of the cannabinoids to receptors, and CBD prevents the breakdown of internally produced cannabinoids.

To Wrap Up: CBD Tolerance

Can you build a tolerance to CBD? Yes, it’s possible.

However, CBD’s unique interaction with cannabinoid receptors makes it difficult to study the mechanisms for tolerance. CBD has such varied effects on individuals long term that people may experience the phenomenon of reverse tolerance, but there’s still more research to be done to substantiate this.

What do you do if your CBD product is no longer working as well as it should or if you’ve never had any luck with CBD?

Make sure you’re buying CBD from reputable brands. There’s a lot of misinformation surrounding CBD — steer clear from brands offering too-good-to-be-true medical claims.

Look for brands that opt for non-biased third-party lab testing to prove the product’s CBD content and safety.

Additionally, you should experiment with your doses and delivery methods (as your needs may change over time), and if you’ve built a tolerance to CBD, it’s a good idea to take a break once in a while.

Luckily, CBD is a well-tolerated compound, and there are many different delivery methods you can experiment with to help you find the most desired outcome. If you’re interested in learning more about CBD, visit our blog for more resources.


The statements made regarding these products have not been evaluated by the Food and Drug Administration. These products are not intended to diagnose, treat, cure or prevent any disease. All information presented here is not meant as a substitute for or alternative to information from health care practitioners. Please consult your health care professional about potential interactions or other possible complications before using any product.

Optimize Your CBD Routine: Defining CBD Tolerance and Other Tips

What does it mean to tolerate something? For most, the word tolerance boils down to gradually learning to put up with something previously deemed irritating or overstimulating, or to adapt to a stimulus that is foreign to the body. If we nix the negative connotation often tied to tolerating a person or thing, CBD tolerance has a similar overall meaning.

Building tolerance to CBD means your endocannabinoid system overly adapted to your standard CBD dosage and is no longer producing the desired results. Whether you use CBD to target chronic pain, inflammation, anxiety, insomnia or other health conditions, it is important for you to find a dosage where the positive effects produced by hemp-derived cannabis compounds can continue at a consistent dosage. Although it is highly unlikely you will develop a CBD tolerance significant enough to hinder the cannabinoids’ positive physiological effects, it is still important to understand the steps you can take to optimize CBD’s impact on your body.

Defining CBD Tolerance

Unlike other drug tolerances, studies show CBD tolerance does not lead to CBD dependency or addiction. In fact, a study published in Integrative Medicine: A Clinician’s Journal shows a daily CBD regimen has the potential to treat marijuana addiction due to CBD’s low levels of THC and overall nonaddictive, nonpsychoactive properties. 1

Tolerance, when looking specifically at CBD, means your body acclimated to your current regimen and now requires a slightly higher dosage to achieve the same results. Don’t worry, as this is a completely normal response within your body! In fact, developing a tolerance to low-potency CBD signals your body is effectively working to achieve equilibrium, a state of internal balance.

How CBD Tolerance Begins

When you first begin taking CBD, your body may not immediately respond to the unfamiliar cannabinoids entering your system. Over time, the endocannabinoid system adapts to the new influx of cannabis plant compounds and responds by activating the cannabinoid receptors that work to regulate conditions like chronic pain, inflammation, anxiety, insomnia and more. The CBD dosage you begin at could very well be the perfect dosage for you, continuously working to balance your unique conditions under a typical daily regimen.

If you begin your CBD regimen at a relatively low dosage, however, your body may require more CBD to maintain adequate endocannabinoid system functioning. This could be as simple as switching from .5mL to 1 mL per dose or from a 500mg CBD oil tincture to the more common 1000mg CBD oil tincture, as starting small and titrating up tends to be the best method to find the safest, most impactful daily CBD doses for your body. If you for some reason do not wish to increase your CBD dosage, taking a brief break from your CBD routine may also allow your endocannabinoid system to reset to base levels.

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Understanding Tolerance Vs. Dependence

The critical difference between tolerance to CBD and tolerance to other substances is that while you may not reap the precise level of wellness benefits you once did at a particular dosage, you will also not experience any troubling withdrawal symptoms. Uncomfortable physical withdrawal symptoms are typically what bridges drug tolerance to drug dependence, which tends to be the first phase of drug addiction.

In contrast to drug dependence or addiction, the CBD-producing hemp plant’s ideal balance of cannabinoids, terpenes and ultra-low levels of THC allow it to effectively treat conditions without overstimulating cannabinoid receptors unlike THC in high-potency recreational or medical marijuana. What happens when cannabinoid receptors are consistently overstimulated by high-THC products? Following euphoric highs and other psychoactive effects, once overused, users will experience a gradually weakened impact causing opposite effects in the form of drug-dependent withdrawal symptoms.

In addition to curbing marijuana addiction, a study of individuals with a history of heroin abuse showed CBD was an effective treatment to reduce drug cues such as cravings, rapid heart rate and elevated cortisol, 2 providing further validation that CBD is not only nonaddictive but may also aid individuals in breaking addictive tendencies without adverse effects.

Are You at Risk of CBD Tolerance?

While it is necessary for your body to learn to tolerate the various hemp-derived CBD compounds upon beginning a regimen, the simple answer is probably not, as developing a tolerance to CBD that inhibits an adequate endocannabinoid system response is highly unlikely. There is no current data of CBD users developing tolerances from too much CBD and Farmulated has personally never received any tolerance-related customer feedback.

Tips to Optimize Your CBD Dosage

This is great news for the thousands of people curious about CBD or just beginning to sample dosages for an effective daily routine. For those still concerned about optimizing their CBD dosage to achieve the best response, here are a few things to consider:

1. Full spectrum CBD oil offers the greatest opportunity to target troubling conditions.

This is because a full spectrum of cannabinoids, terpenes and low-level THC can trigger what is known as the entourage effect, which is best summarized as the whole being greater than the sum of its parts, aka hundreds of cannabis compounds. Isolate, or pure cannabis oil extract, is still a great option for those looking to completely avoid THC but may not produce as comprehensive of results.

2. 1000mg CBD oil will have a profoundly different effect than 500mg CBD oil.

1000mg CBD oil is double the potency of 500mg oil, serving up 33.33mg of hemp-derived CBD extract per 1 mL dose versus 16.67mg per dose. Not all 30 mL CBD bottles are created equal, and while a 500mg bottle of CBD oil may provide a perfect dosage for a friend, your body may require the 1000mg CBD bottle.

3. CBD oil is faster-acting than CBD topicals, capsules and edibles.

If you begin a CBD oil regimen and then switch over to a different form of CBD, you may notice a lack of results in the hours after consumption or application. This is because the sublingual, or “under-the-tongue”, delivery system of oil allows CBD to dissolve into your bloodstream more rapidly. We at Farmulated recommend those maintaining CBD regimens to always include CBD oil to maintain consistent therapeutic effects, then add CBD topicals, capsules and edibles as needed.

4. The quality of your CBD is critical to achieving results.

In a saturated market of low-quality cannabis products, there tends to be plenty of outsourced CBD companies concealing ingredient lists or worse, pushing cheap hempseed oils masquerading as CBD! To break through the abundance of CBD industry noise, we at Farmulated always provide customers a third party-tested certificate of analysis identifying the full chemical composition of our CBD products, including the precise percentage of hemp-derived CBD extract. Without knowing how much CBD you are ingesting, it is impossible to gauge if your CBD products are working effectively.

For us at Farmulated, crafting safe, effective CBD products that will work for our customers has always been our goal, and one best accomplished by growing our own hemp for quality control, creating products with different potencies and delivery systems for individual needs and third-party testing our formulations for full customer transparency. Keeping these principles in mind, the proper dosage should prevent CBD tolerance while improving your overall health and wellness for many years to come!

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